How to use in-sentence of “nucleophile”:
– But in a S2 reaction, the nucleophile forces off the leaving group in the limiting step.
– In the S1 reaction, the nucleophile attacks after the rate-limiting step is over.
– Nucleophilicity, sometimes referred to as nucleophile strength, refers to a substance’s nucleophilic character and is often used to compare the attraction of atoms.
– The nucleophile attacks the carbon at 180° to the leaving group, since this provides the best overlap between the nucleophile‘s lone pair and the C-X σ* antibonding orbital.
– If an attempt is made to perform an S1 reaction using a strongly basic nucleophile such as hydroxide or methoxide ion, the alkene will again be formed, this time via an E2 elimination.
– In cases where both mechanisms are possible, the mechanism depends on solvent, temperature, concentration of the nucleophile or on the leaving group.
